Henry Harrison may refer to:

• Henry Harrison (Philadelphia mayor) (1713–1766), American mayor of Philadelphia, Pennsylvania
• Henry Harrison (c. 1736–1772), brother of Benjamin Harrison V, officer during the French and Indian War
• Henry Harrison (Cranford mayor), American mayor of Cranford, New Jersey
• Henry Baldwin Harrison (1821–1901), Connecticut Governor
• Henry Thomas Harrison (1832–1923), spy during the American Civil War
• H. C. A. Harrison (Henry Colden Antill Harrison, 1836–1929), Australian rules football pioneer
• Henry Harrison (Irish politician) (1867–1954), Irish Protestant Nationalist politician and writer, M.P. for Mid-Tipperary, 1890–1892
• Henry Sydnor Harrison (1880–1930), American novelist
• Henry Harrison, member of rock band Mystery Jets
• Henry Shafto Harrison (1810–1892), New Zealand politician
• Henry G. Harrison (1813–1895), English architect
• Henry Harrison (New York politician) (1854–1935), American businessman and politician
• Henry Harrison (cricketer) (1883–1971), English cricketer